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Tuesday, August 11, 2020 | History

4 edition of Response to issues and data submissions on the carcinogenicity of tetrachloroethylene (perchloroethylene) found in the catalog.

Response to issues and data submissions on the carcinogenicity of tetrachloroethylene (perchloroethylene)

Response to issues and data submissions on the carcinogenicity of tetrachloroethylene (perchloroethylene)

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Published by Human Health Assessment Group, Office of Health and Environmental Assessment, U.S. Environmental Protection Agency in Washington, D.C .
Written in English

    Subjects:
  • Tetrachloroethylene -- Carcinogenicity

  • Edition Notes

    ContributionsUnited States. Environmental Protection Agency. Office of Health and Environmental Assessment. Human Health Assessment Group
    The Physical Object
    FormatMicroform
    Paginationvii, 73 p.
    Number of Pages73
    ID Numbers
    Open LibraryOL14456891M
    OCLC/WorldCa33018035

    Get this from a library! NTP technical report on the toxicology and carcinogenesis tetrachloroethylene (perchloroethylene) (CAS. no. ) in F/N rats and B6C3F1 mice (inhalation studies). [National Toxicology Program (U.S.);]. Evaluation: No epidemiological data relevant to the carcinogenicity of 1,1,1,2-tetrachloroethane were available. There is limited evidence in experimental animals for the carcinogenicity of 1,1,1,2-tetrachloroethane. Overall evaluation: 1,1,1,2-Tetrachloroethane is not classifiable as to its carcinogenicity to humans (Group 3).

    Lifestyle factors and chronic pathologic states are important contributors to interindividual variability in susceptibility to xenobiotic-induced toxicity. Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent condition that can dramatically affect chemical metabolism. We examined the effect of NAFLD on toxicokinetics of tetrachloroethylene (PERC), a ubiquitous environmental.   New Policy. For the past 20 plus years, NIOSH has subscribed to a carcinogen policy that was published in by Edward J. Fairchild, II, Associate Director for Cincinnati Operations, which called for “no detectable exposure levels for proven carcinogenic substances” (Annals of the New York Academy of Sciences, , ).

    mouse carcinogenicity studies and whether the use of rats or mice alone would result in a significant loss of information on carcinogenicity relevant to human risk assessment has been addressed by six surveys of the data for human pharmaceuticals. The surveys were those of. Hill Air Force Base. The Hill Air Force Base occupational cohort has been described in detail previously. 1, 2, 7 Briefly, in the early s, the NCI assembled this cohort to study the mortality impact of occupational exposure to organic solvents, in particular, TCE. The cohort is composed of 14, civilians employed at this aircraft maintenance facility for at least one year between 1.


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Response to issues and data submissions on the carcinogenicity of tetrachloroethylene (perchloroethylene) Download PDF EPUB FB2

EPA///F September RESPONSE TO ISSUES AND DATA SUBMISSIONS j ON THE CARCINOGENICITY OF TETRACHLOROETHYLENE (PERCHLOROETHYLENE) Human Health Assessment Group • Office of Health and Environmental Assessment U.S.

Environmental Protection Agency Washington, D.C. ; Printed on Recycled Paper. Get this from a library. Response to issues and data submissions on the carcinogenicity of tetrachloroethylene (perchloroethylene).

[United States. Environmental Protection Agency. Office of Health and Environmental Assessment. Human Health Assessment Group.;]. The objective is to revisit issues and review data concerning the identification of hazard, i.e., the weight of the animal evidence bearing on the potential for human carcinogenicity.

Data have been submitted and issues raised in public comment connected with a variety of recent Agency rule- making actions. Tetrachloroethylene (Perchloroethylene) Hazard Summary Tetrachloroethylene is widely used for dry-cleaning fabrics and metal degreasing operations.

Effects resulting from acute (short term) high-level inhalation exposure of humans to tetrachloroethylene include irritation of the upper respiratory tract and eyes, kidney dysfunction, and neurological effects such as reversible mood and behavioral changes.

Evaluation of experimental evidence of carcinogenicity. There is clear evidence of PCE carcinogenicity in rodents: one oral gavage [National Cancer Institute (NCI) ] and two inhalation [Japan Industrial Safety and Health Association (JISA) ; National Toxicology Program (NTP) ] cancer bioassays, all in sexually mature animals.

No data were available on cancer risks Cited by: Michelle J. Hooth, Kevin S. McDorman, Susan D. Hester, Michael H. George, Lance R. Brooks, Adam E.

Swank, Douglas C. Wolf, The Carcinogenic Response of Tsc2 Mutant Long-Evans (Eker) Rats to a Mixture of Drinking Water Disinfection By-Products Was Less Than Additive, Toxicological Sciences, Vol Issue 2, OctoberPages – Epidemiological studies concerning the carcinogenicity of tetrachloroethylene in humans are limited principally to investigations of workers employed in the dry-cleaning and laundry industries (usually combined), who were likely exposed to several substances in addition to tetrachloroethylene, and for whom quantitative data on cumulative exposure were not available.

Trichloroethylene (CICH=CCl 2) is a colorless liquid with a chloroform-like odor. Trichloroethylene may cause irritation to the eyes and skin. Exposure to high concentrations can cause dizziness, headaches, sleepiness, confusion, nausea, unconsciousness, liver damage, and even death.

Trichloroethylene is a known carcingen. Respective A and SEE values of and for tetrachloroethylene and and for trichloroethylene were obtained from SKC Samplers to give DLOPs of µg of tetrachloroethylene per sample (31 ppb or µg/m 3) and µg.

response, normally the geometric mean (2, 6, 18) (2root of 2*18) High dose (MTD from one month) Low dose (No effect level or multiple of intended therapeutic dose) Mid-dose: to give a dose-response, normally the geometric mean (1, 3, 6) General toxicology. Paulu C, Aschengrau A, Ozonoff D. Tetrachloroethylene-contaminated drinking water in Massachusetts and the risk of colon-rectum, lung, and other cancers.

Environ Health Perspect (4) Chiu WA, Jinot J, Scott CS, Makris SL et al. Human health effects of trichloroethylene: key findings and scientific issues. Current View: Immuno; (sorted by first author) Results: Page of 13 Sort By: firstauthor asc. STUDY DATA SUBMISSION FORMAT 3.

Record significant data issues, clarifications, explanations of traceability, and Data about a library book such as author, type of book. Provide broad input on scientific issues or policy issues related to carcinogenicity • The Chair of the CAC will: 1.

Lead the meeting. Sign the minutes • The Executive Secretary will: 1. Although carcinogenicity studies concerning tetrachloroethylene have largely focused on the inhalation route of exposure, carcinogenicity has also been reported following oral exposure.

The NTP () and JISA () inhalation studies provide the best data for assessment of. Trichloroethylene (TCE) is a well-known carcinogen in rodents and concerns exist regarding its potential carcinogenicity in humans.

Oxidative metabolites of TCE, such as dichloroacetic acid (DCA) and trichloroacetic acid (TCA), are thought to be hepatotoxic and carcinogenic in mice. • Tetrachloroethylene (Perc) (Final, ) Hazard Genotox • Trichloroacetic acid (TCA) (Final, ) • Trichloroethylene (TCE) (Final, ) All References Hazard Cancer Epi Genotox Kidney Liver Respiratory Dose-Response Non-Cancer Cancer Liver Issues • Trimethylbenzenes (Interagency Science Discussion Draft) Primary Literature Search.

Tetrachloroethylene is a colorless, volatile, nonflammable, liquid, chlorinated hydrocarbon with an ether-like odor that may emit toxic fumes of phosgene when exposed to sunlight or flames.

Tetrachloroethylene is mainly used as a cleaning solvent in dry cleaning and textile processing and in the manufacture of fluorocarbons. The Carcinogenic Potency Data Base (CPDB) has provided a source of study information, complete with calculated TD 50 values.

However, this is no longer actively updated. An understanding of carcinogenic potency, which can be derived from dose–response data, can be used as part of human risk assessments to generate safety thresholds under.

Tetrachloroethylene (PCE), a known carcinogen, has degraded at least wells in the Central Valley of This report discusses some of the data and conclusions about PCE movement to ground water, the source of if a facility is listed as a dry cleaner in the phone book and the questionnaire response says it is only a transfer station and.

Group B - Probably Carcinogenic to Humans: Agents with sufficient evidence (i.e., indicative of a causal relationship) from animal bioassay data, but either limited human evidence (i.e., indicative of a possible causal relationship, but not exclusive of alternative explanations; Group B1), or with little or no human data (Group B2).Other commenters echoed the view of the SIRC.

For example, a paper prepared by the Epidemiology Department of the Dow Chemical Company and reported on in Dow’s prehearing submission (Ex.p. 55) concludes: “[O]verall these data do not support a causal link between lymphatic and hematopoietic cancer and styrene.”.A) was the first book that discussed water pollution problems in Lake Apopka B) was the first book that discussed environmental problems with DDT C) focused on the impacts of endocrine-disrupting chemicals on humans D) was the first book to dispute claims in Rachel Carson's book Silent Spring.